AUTOaivo AUTObrain AUTOmation and brain research

AUTO3050 Physiological psychology
AUTO3130 Medical Imaging
AUTO3220 (NIR) Spectroscopy
J. V. Frangioni's group (Photo (c) Steve Gilbert)
J. Hernesniemi

Tiivistelmä / Abstract

AUTOaivo sivulla on linkkejä aivojen kuvantamiseen yms. ja erityisesti siinä käytettyihin loisteaineisiin varsinkin lähi-infrapunalla toimivaan indosyaniinivihreään.

Sivu on tuotettu FIELD NIRce hankkeessa, joka on EU;n Botnia-Atlantica -ohjelman osahanke.

AUTObrain page contains links to brain imaging and similar pages especially to contrast agents used in imaging, in particular to papers using near-infrared fluorescent indocyanine green.

This page is produced in FIELD NIRce project which is a subproject of Bothnia-Atlantica.

Status (tasks)

Tasks done

Tasks to be done

This project is currently (Feb 2009) in a planning phase consisting of at least the following subtasks to be done:
  • a slide show to give a motivation and background for activities related to brain imaging in AUTOmation
  • Links to related work;
  • links to brain imaging systems
  • links to brain surgery etc

Labwork topics for AUTOcourses etc:


Brain imaging, cameras, etc
  • under construction ...
Brain diseases
  • under construction ...


Early papers
Brain imaging:
Brain ICG imaging
Brain NIR tomography
ICG in surgery (soldering etc)
Indocyanine green
Properties of ICG:

Online Medical Dictionary:
Chemical name: 1H-Benz(e)indolium, 2-(7-(1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz(e)indol-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt

CAS: 3599-32-4

Acros Organics / ICG laser grade.

Aldrich Suomi:

In vivo:
ICG is irreversibly removed by hepatocytes (liver cells). Therefore it can be used to estimate hepatic (liver) blood flow in addition to cardiac output and blood volume in humans. Plasma half-life is 3 to 4 min. The recommended dose for ICG angiography is 0.2-0.5mg/kg, the maximum daily dose should not exceed 5 mg/kg. /med:ARaabe05b/ ICG in (brain) oncology
ICG in laser neurosurgery
  • M. Sato, M. Ishihara, T. Arai, T. Asazuma, T. Kikuchi, T. Hayashi, T. Yamada, M. Kikuchi & K. Fujikawa, Use of new ICG-dye-enchanced diode laser for percutaneous laser disc decompression, Lasers in Surgery and Medicine, Vol. 29, pp. 282-287, 2001. med:MasatoSato01a
    Selkärangan välilevyn laserkirurgiakoe diodilaserilla ja ICG:llä koirilla (beagle). Diode laser surgery of dog vertebrae (backbone) lumbar disc with ICG-dye.
ICG in oncology
ICG in angiography (new applications)
ICG toxicity and photodynamic therapy (PDT)
Tomography development with ICG
Other medical ICG applications:
Other NIR dyes
There are also some other NIR dyes (under development mainly):
Other fluorescent dyes
Tissue optics
Optics and optical properties of tissues and liquids: Modeling and simulation
  • D. M. Sforza, C. M. Putman and J. R. Cebral, Hemodynamics of cerebral aneurysms, Annual Review of Fluid Mechanics, Vol. 41, pp. 91-107, 2009. med:DMSforza09a
    A review of recent progress on the mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.
Genetic algorithms and brains:
Being one of the most active genetic algorithm optimisation groups, it is most natural to see what retina related research already exists.

See GAs in Medicine (.pdf)

Here some references:
  • Under construction....

Sanastoa / Vocabulary

For engineers not so familiar with medical terminology:

aneurysm verisuonen laajentuma
angiography verisuonikuvantaminen
artery valtimo
capillary hiussuoni
contrast agent/medium varjoaine (tässä oik. loisteaine)
erythrocyte punasolu
in silico computationally
in vitro off line, "vitriinissä"
in vivo on line, in live organism
neutrophil granulocyte valkosolu
reticulocyte nuori punasolu
vein laskimo
vessel suoni

Lyhenteitä / Abbreviation

BOLD Blood Oxygenation Level-Dependent
BLI BioLuminescence Imaging
CCD Charge-Coupled Device (camera)
CT Computed Tomography
GA Genetic Algorithm
ICG IndoCyanine Green
ICGA ICG angiographybr> MRI Magnetic Resonance Imaging
NIOM NIR Operating Microscope
NIR Near-InfraRed
NIRF Near-InfraRed Fluorescence
NIRS Near-InfraRed Spectroscopy
PDT PhotoDynamic Therapy
PET Positron Emission Tomography
SAH SubarAchnoid Hemorrhage

Osallistujien esittelyt

Seuraavassa listaa potentiaalisista osallistujista:
Nimi Yritys/Organisaatio
Jarmo AlanderVaasan Yliopisto
Petri VälisuoVaasan Yliopisto

Links to some web pages having similar profile

Disclaimer: This webpage is for unofficial communications only,
thus none of the contributors, sponsors, administrators, or anyone else connected with this webpage in any way whatsoever can be responsible for the appearance of any inaccurate or libelous information or for your use of the information contained in or linked from these web pages. In case of any comments, questions, etc please contact:

Contact info
Prof. Jarmo Alander Tel int: +358 29 449 8444,
Dept. of electrical engineering & energy technology mobile: +358 50 5534006,
University of Vaasa
PL / P.O. Box 700, FIN-65101 Vaasa , Finland Home page:

Last modified: 18.02.2013 by jal

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